Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development
| Autor: | Byeong-Sun Choi, Jae Keun Chung, Hye Young Kee, Jee Eun Rhee, Sung Soon Kim, Sang-Kee Min, Seong Joon Kim, Dai-Ho Jang, Choong Mo Kim, Mi Yeong Shin |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Adolescent Genotype Short Report Uterine Cervical Neoplasms HPV vaccines lcsh:Infectious and parasitic diseases Young Adult Papillomavirus Vaccines Asian People Virology Prevalence medicine Humans lcsh:RC109-216 Papillomaviridae Cervix Cervical cancer Korea biology business.industry Papillomavirus Infections Age Factors HPV infection virus diseases Middle Aged biology.organism_classification medicine.disease female genital diseases and pregnancy complications Vaccination Cross-Sectional Studies medicine.anatomical_structure Infectious Diseases DNA Viral Female business |
| Zdroj: | Virology Journal, Vol 7, Iss 1, p 201 (2010) Virology Journal |
| ISSN: | 1743-422X |
| DOI: | 10.1186/1743-422x-7-201 |
| Popis: | We investigated the prevalence of human papillomavirus (HPV) infection and the distribution of high-risk HPV genotypes among 2,308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women (40.7%) but only one-third of women were positive for HPV-16 and/or HPV-18, the genotypes used for developing the HPV vaccines. Thus, the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women. |
| Databáze: | OpenAIRE |
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