T Lymphocyte Subpopulations in Patients with B-Cell Chronic Lymphocyte Leukaemia: Relationship to Infective Episodes
| Autor: | Gauranga Majumdar, N B Westwood, E. R. Copson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Cancer Research Lymphocyte Biology Infections Lymphocyte subpopulations Antigens CD T-Lymphocyte Subsets hemic and lymphatic diseases Immune Tolerance medicine Humans In patient B cell Aged Aged 80 and over Effector Incidence (epidemiology) Hematology T lymphocyte Middle Aged Leukemia Lymphocytic Chronic B-Cell medicine.anatomical_structure Oncology Immunology Female CD5 |
| Zdroj: | Leukemia & Lymphoma. 14:441-446 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199409049701 |
| Popis: | Patients with B-cell chronic lymphocytic leukaemia (B-CLL) have an increased susceptibility to infection. Quantitative abnormalities of T-cells have been previously reported in B-CLL, although the relationship between such abnormalities and the incidence of infection still remains to be established. We therefore enumerated lymphocyte subpopulations in 22 patients with B-CLL grouped according to the number of infective episodes in the previous three years. No significant differences were found between the patient groups and the mean number of T-cells subsets (helper, suppressor, suppressor-inducer and suppressor effector) or NK cells, but patients with frequent infections were found to have significantly higher CD5+ B-cell counts. Thus, we confirm that T-cell subpopulations are numerically altered in patients with B-CLL, but found that such changes are not predictive of susceptibility to infection. Our results however suggest that the malignant B-cells may exhibit immunosuppressive activity. |
| Databáze: | OpenAIRE |
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