Breastfeeding in children of women taking antiepileptic drugs: Cognitive outcomes at age 6 years
| Autor: | Kimford J, Meador, Gus A, Baker, Nancy, Browning, Morris J, Cohen, Rebecca L, Bromley, Jill, Clayton-Smith, Laura A, Kalayjian, Andres, Kanner, Joyce D, Liporace, Page B, Pennell, Michael, Privitera, David W, Loring, Thad, Zajdowicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Developmental Disabilities Intelligence Breastfeeding Breast milk Pregnancy medicine Humans Prospective Studies Pediatrics Perinatology and Child Health Child Adverse effect Prospective cohort study Intelligence Tests Epilepsy Intelligence quotient business.industry medicine.disease United Kingdom United States Breast Feeding Differential Ability Scales Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Anticonvulsants Female Cognition Disorders business Breast feeding |
| Zdroj: | Meador, K J, Baker, G A, Browning, N, Cohen, M J, Bromley, R L, Clayton-Smith, J, Kalayjian, L A, Kanner, A, Liporace, J D, Pennell, P B, Privitera, M & Loring, D W 2014, ' Breastfeeding in children of women taking antiepileptic drugs: Cognitive outcomes at age 6 years ', JAMA pediatrics, vol. 168, no. 8, pp. 729-736 . https://doi.org/10.1001/jamapediatrics.2014.118 Meador, K J, Baker, G A, Browning, N, Cohen, M J, Bromley, R L, Clayton-Smith, J, Kalayjian, L A, Kanner, A, Liporace, J D, Pennell, P B, Privitera, M & Loring, D W 2014, ' Breastfeeding in children of women taking antiepileptic drugs: Cognitive outcomes at age 6 years ' JAMA pediatrics, vol. 168, no. 8, pp. 729-736 . https://doi.org/10.1001/jamapediatrics.2014.118 |
| Popis: | IMPORTANCE Breastfeeding is known to have beneficial effects, but concern exists that breastfeeding during maternal antiepileptic drug (AED) therapymay be harmful.We previously noted no adverse effects of breastfeeding associated with AED use on IQ at age 3 years, but IQ at age 6 years is more predictive of school performance and adult abilities. OBJECTIVES To examine the effects of AED exposure via breastfeeding on cognitive functions at age 6 years. DESIGN, SETTING, AND PARTICIPANTS Prospective observational multicenter study of long-term neurodevelopmental effects of AED use. Pregnant women with epilepsy receiving monotherapy (ie, carbamazepine, lamotrigine, phenytoin, or valproate) were enrolled from October 14, 1999, through April 14, 2004, in the United States and the United Kingdom. At age 6 years, 181 children were assessed for whom we had both breastfeeding and IQ data. All mothers in this analysis continued taking the drug after delivery. MAIN OUTCOMES AND MEASURES Differential Ability Scales IQwas the primary outcome. Secondary measures included measures of verbal, nonverbal, memory, and executive functions. For our primary analysis, we used a linear regression model with IQ at age 6 years as the dependent variable, comparing children who breastfed with those who did not. Similar secondary analyses were performed for the other cognitive measures. RESULTS In total, 42.9%of children were breastfed a mean of 7.2 months. Breastfeeding rates and duration did not differ across drug groups. The IQ at age 6 years was related to drug group (P |
| Databáze: | OpenAIRE |
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