Association of factor VII genotype with plasma factor VII activity and antigen levels in healthy Indian adults and interaction with triglycerides
| ISSN: | 1049-8834 |
|---|---|
| DOI: | 10.1161/01.atv.14.12.1923 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5723318a49f78f3519e8e1efb25c54 https://doi.org/10.1161/01.atv.14.12.1923 |
| Rights: | OPEN |
| Přírůstkové číslo: | edsair.doi.dedup.....9a5723318a49f78f3519e8e1efb25c54 |
| Autor: | John S. H. Tay, Low Ps, Yang Liu, Shuzhen Hong, Nilmani Saha, Chew-Kiat Heng |
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Molecular Sequence Data India Plasma factor Factor VIIa Autoantigens White People chemistry.chemical_compound Antigen Internal medicine Blood plasma Confidence Intervals medicine Humans Allele Triglycerides Aged Analysis of Variance Singapore Polymorphism Genetic Base Sequence Triglyceride Factor VII business.industry Middle Aged Confidence interval Endocrinology chemistry Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 14:1923-1927 |
| ISSN: | 1049-8834 |
| DOI: | 10.1161/01.atv.14.12.1923 |
| Popis: | Plasma factor VII activity (factor VIIc) is one of the independent risk factors for coronary artery disease and is controlled by both genetic and environmental factors. Several studies in healthy Caucasian subjects have revealed an association of a common genetic polymorphism at residue 353 (Arg-->Gln) of the factor VII gene with plasma factor VIIc. We have investigated the influence of this polymorphism (factor VII Arg/Gln353) on fasting plasma factor VIIc and antigen (factor VIIag) levels and its interaction with triglyceride levels in 185 healthy Dravidian Indians of both sexes (128 men, 57 women). The frequency of Gln353 has been found to be significantly higher in Dravidian Indians (0.29; confidence interval, 0.27 to 0.30) than in Caucasians (0.10). The distribution of factor VII Arg/Gln353 genotypes was at Hardy-Weinberg equilibrium. The carriers of the Gln353 allele had significantly lower plasma factor VIIc and factor VIIag in men (P < .05). The factor VII Arg/Gln353 polymorphism explained 13% and 11% of the total variance of plasma factor VIIc and factor VIIag, respectively, in men (P < .001) and 6% and 9% in women (P > .1). The genotype-specific correlation of factor VIIc and factor VIIag with triglyceride levels was stronger in carriers of the Gln353 allele (r = .38 and .41; P < .001) than in Arg353 homozygotes (r = .09 and .27; P = .19 and .005, respectively). |
| Databáze: | OpenAIRE |
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