Combined Application of Human Amniotic Membrane Wrapping and Hyaluronic Acid Injection in Epineurectomized Rat Sciatic Nerve

Autor: Güzin Yeşim Özgenel, Gülaydan Filiz
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı., Özgenel, Güzin Yeşim, Filiz, Gülaydan, AAH-4233-2021
Rok vydání: 2004
Předmět:
Male
Pathology
Neuroma
Median Neuropathy
Phantom Limb
Adhesions
Scar tissue
Median nerve
Adhesion (medicine)
Tissue Adhesions
Neurectomy
Biological dressings
Animal tissue
Rats
Sprague-Dawley
chemistry.chemical_compound
Scar
Peripheral Nerve Injuries
Epineurium
Hyaluronic acid
Peripheral nerves
Priority journal
Skin
Amnion
Human amniotic membrane
Combined modality therapy
Adjuvants
immunologic
Anatomy
Peripheral nerve scarring
Membrane
medicine.anatomical_structure
Models
animal
Adhesion
Muscle
Rabbits
Fluid
Sciatic nerve
Human
medicine.medical_specialty
Histology
Carpal-tunnel syndrome
Injections
intralesional
Article
Scar formation
Graft
Adjunct
Cicatrix
Peripheral nerve
medicine
Animals
Animal model
Human tissue
Transplantation
business.industry
Sciatic neuropathy
Nerve compression
Nonhuman
medicine.disease
Flap
Peripheral-nerve
Neuropathy
Rats
chemistry
Rat
Surgery
business
Zdroj: Journal of Reconstructive Microsurgery. 20:153-157
ISSN: 1098-8947
0743-684X
DOI: 10.1055/s-2004-820772
Popis: The purpose of this study was to investigate the effects of combined application of human amniotic membrane wrapping and hyaluronic acid injection on peripheral nerve scarring in an adult rat model. After circumferential epineurectomies of right sciatic nerves were performed in each of 72 rats, nerves were randomly divided into three groups: (1) nothing was done additional to epineurectomy; (2) the epineurectomized segment was wrapped with human amniotic membrane; and (3) the epineurectomized segment was wrapped with human amniotic membrane and hyaluronic acid was injected inside. The extent of adhesions and perineurial scar thickness was macroscopically and histologically evaluated at 4 and 12 weeks. The least adhesion and perineurial scar tissue were observed in nerves treated with human amniotic membrane wrapping and hyaluronic acid injection. This combination appears to be safe and effective in preventing perineurial scar formation after peripheral nerve surgery in rats.
Databáze: OpenAIRE
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