Cephalosporins. II. Synthesis and structure-activity relationships of new 7-vinylenethioacetamido and thioacrylamido cephalosporins

Autor:	Ettore Perrone, Giuliano Nannini, G. Meinardi, Dino Severino, Giovanni Biasoli, Angelo Bedeschi, Alberta Bianchi
Rok vydání:	1981
Předmět:	Pharmacology Vinyl Compounds biology Bacteria Chemical Phenomena Stereochemistry medicine.drug_class Chemistry Cephalosporin Cefazolin Thioacetamide biology.organism_classification In vitro Cephalosporins Structure-Activity Relationship Acrylates Drug Discovery medicine medicine.drug
Zdroj:	The Journal of antibiotics. 34(4)
ISSN:	0021-8820
Popis:	The synthesis and in vitro structure-activity relationships of 7-vinylenethioacetamido and thioacrylamido cephalosporins with various substituents at the 3-position are described. 7(Z)-beta-Vinylenethioacetamido cephalosporins proved the most active against Gram-positive and Gram-negative bacteria. 7-[(Z)-beta-Cyanovinylenethioacetamido]-3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-3-cephem-4-carboxylic acid (K 13101, 40) was several times more active in vitro than cefazolin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a55408d640dac9eecc21bbd130e8fd7 https://pubmed.ncbi.nlm.nih.gov/7275820 Zobrazit plný text záznamu