Histamine in the kidneys: what is its role in renal pathophysiology?
| Autor: | Arianna Carolina Rosa, Maura Gurrieri, Roberta Verta, Roberto Fantozzi, Cristina Grange, Alessandro Pini |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Renal function Pharmacology Kidney Themed Section: Review Articles 03 medical and health sciences chemistry.chemical_compound Histamine receptor 0302 clinical medicine Histamine H2 receptor Animals Humans Medicine Receptor business.industry Hemodynamics Histaminergic 030104 developmental biology medicine.anatomical_structure chemistry Renal physiology Receptors Histamine business 030217 neurology & neurosurgery Histamine |
| Zdroj: | Br J Pharmacol |
| Popis: | Starting with a role for histamine role in renal haemodynamics, evidence has accumulated, over time, suggesting a wider range of actions on renal function and this has renewed interest in the pathophysiological role of histamine in the kidney. Here we provide an up‐to‐date review of this topic. As the kidney expresses enzymes that synthesize and metabolise histamine, along with its receptors, all the components for histaminergic transmission are present in this tissue. The distribution of histamine receptors matches a wide range of effects. We address the questions of the redundancy of H(1) and H(2) receptors in renal haemodynamics, the complementary role of H(1) and H(4) receptors in renal filtration and reabsorption, and the dichotomy between local and neuronal H(1) and H(3) receptors. Experimental models of renal disease raise the possibility of new therapeutic approaches based on histamine. The effects of histamine on renal function are not yet fully understood and their elucidation is still ongoing. LINKED ARTICLES: This article is part of a themed section on New Uses for 21st Century. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc |
| Databáze: | OpenAIRE |
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