Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations
| Autor: | Kenysha Y. J. Clear, Beth Uberseder, Carol A. Shively, Akiko Chiba, Thomas B. Clarkson, Adam S. Wilson, Thomas C. Register, Janet A. Tooze, Katherine L. Cook, Susan E. Appt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mediterranean diet medicine.drug_class Metabolite Mammary gland Physiology Diet Mediterranean General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Mammary Glands Animal biology.animal Lactobacillus medicine Animals Primate Microbiome lcsh:QH301-705.5 biology Bile acid Microbiota Haplorhini biology.organism_classification medicine.disease 030104 developmental biology medicine.anatomical_structure chemistry lcsh:Biology (General) Diet Western 030220 oncology & carcinogenesis Female |
| Zdroj: | Cell Reports, Vol 25, Iss 1, Pp 47-56.e3 (2018) |
| ISSN: | 2211-1247 |
| Popis: | Summary: Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negative regulator of breast cancer. Diet is a main determinant of gut microbial diversity. Whether diet affects breast microbiome populations is unknown. In a non-human primate model, we found that consumption of a Western or Mediterranean diet modulated mammary gland microbiota and metabolite profiles. Mediterranean diet consumption led to increased mammary gland Lactobacillus abundance compared with Western diet-fed monkeys. Moreover, mammary glands from Mediterranean diet-fed monkeys had higher levels of bile acid metabolites and increased bacterial-processed bioactive compounds. These data suggest that diet directly influences microbiome populations outside the intestinal tract in distal sites such as the mammary gland. Our study demonstrates that diet affects the mammary gland microbiome, establishing an alternative mechanistic pathway for breast cancer prevention. : Using a non-human primate model of women’s health, Shively et al. demonstrate that diet plays a critical role in determining microbiota populations in tissues outside the gut, such as the mammary gland. These microbial populations modulate localized bile acid and bacterial-modified metabolites to potentially influence anticancer signaling pathways. Keywords: breast, mammary gland, diet, microbiome, bile acid, hippurate, oxidative stress |
| Databáze: | OpenAIRE |
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