| Autor: |
Kwun Kiu Wong, Feifei Cheng, Di Mao, Cadmon K P Lim, Claudia H T Tam, Chi Chiu Wang, Lai Yuk Yuen, Michael H M Chan, Chung Shun Ho, Mugdha V Joglekar, Anandwardhan A Hardikar, Alicia J Jenkins, Boyd E Metzger, William L Lowe, Wing Hung Tam, Ronald C W Ma |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
J Clin Endocrinol Metab |
| ISSN: |
1945-7197 |
| Popis: |
Context Leukocyte telomere length (LTL) is a biomarker of biological aging and is associated with metabolic diseases such as type 2 diabetes. Insufficient maternal vitamin D was associated with increased risk for many diseases and adverse later life outcomes. Objective This study investigates the relationship between vitamin D levels and offspring LTL at early life. Methods This observational, longitudinal, hospital-based cohort study included eligible mother-child pairs from the HAPO Hong Kong Field Centre, with 853 offspring at age 6.96 ± 0.44 (mean ± SD) years. LTL was measured using real-time polymerase chain reaction while serum vitamin D metabolites 25(OH)D2, 25(OH)D3, and 3-epi-25(OH)D3 were measured in maternal blood (at gestation 24-32 weeks) and cord blood by liquid chromatography–mass spectrometry. Results LTL at follow-up was significantly shorter in boys compared with girls (P Conclusion Our findings suggest 25(OH)D3 and 3-epi-25(OH)D3 in utero may impact on childhood LTLs, highlighting a potential link between maternal vitamin D and biological aging. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
