High-dose, short-term local urokinase for clearing femoral thrombi by vasodilation and thrombolysis
| Autor: | William Callahan, Howard V. Hufnagel, Nelson J. Gurll |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Vasodilator Agents
medicine.medical_treatment Vasodilation Femoral artery Dogs Fibrinolytic Agents medicine.artery Endopeptidases medicine Animals Urokinase Dose-Response Relationship Drug business.industry Fibrinolysis Thrombosis Arterial blood flow Thrombolysis Urokinase-Type Plasminogen Activator Femoral Artery Radiography Injections Intra-Arterial Anesthesia Systemic administration Surgery business medicine.drug |
| Zdroj: | Journal of Surgical Research. 20:381-388 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(76)90109-8 |
| Popis: | 1. 1. Intra-arterial infusion of urokinase results in a sustained increase in femoral arterial blood flow which is dose- and preparation-related. 2. 2. This vasodilation is separable from the fibrinolytic activity of urokinase since the latter but not the former is attenuated by inhibition of plasminogen activation. 3. 3. Intra-arterial infusion of urokinase induces a local fibrinolytic state which is more effective than systemic administration in achieving thrombolysis. 4. 4. Similar doses are required for vasodilation and local fibrinolysis-thrombolysis, thus suggesting the clinical use of intra-arterial urokinase in thrombotic occlusions of the femoral artery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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