Serum Calprotectin is Indicating Clinical and Ultrasonographic Disease Activity in Rheumatoid Arthritis, even with Normal C-Reactive Protein Levels
| Autor: | Emine Uslu Yurteri, Gülay Kinikli, Ebru Us, Emine Gözde Aydemir Gülöksüz, Murat Torgutalp, Tahsin Murat Turgay, İlyas Ercan Okatan, Aşkın Ateş, Serdar Sezer, Müçteba Enes Yayla, Ayşe Bahar Keleşoğlu Dinçer, Didem Sahin Eroglu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
rheumatoid arthritis
medicine.medical_specialty Diseases of the musculoskeletal system calprotectin Gastroenterology fluids and secretions Rheumatology Synovitis Internal medicine Medicine Univariate analysis Original Paper biology Receiver operating characteristic medicine.diagnostic_test business.industry ultrasound C-reactive protein acute phase ultrasonography medicine.disease RC925-935 Erythrocyte sedimentation rate Rheumatoid arthritis biology.protein Biomarker (medicine) biomarker Calprotectin business |
| Zdroj: | Mediterranean Journal of Rheumatology, Vol 32, Iss 1, Pp 56-65 (2021) Mediterranean Journal of Rheumatology |
| Popis: | Objective: Calprotectin is an inflammatory biomarker which assesses disease activity in rheumatoid arthritis (RA). The objective of this study was to test whether serum calprotectin is associated with clinical and ultrasonographic disease activity in patients with RA, and to analyse its predicting value for disease activity evaluation despite normal C-Reactive protein (CRP) levels. Methods: We included 80 patients with RA and 30 healthy subjects. Patients were examined clinically and by ultrasound, (US7 score) along with laboratory parameters (calprotectin, CRP, erythrocyte sedimentation rate [ESR]). Disease activity scores (DAS28) were calculated to assess disease activity. Firstly, patients were divided into four subgroups according to the DAS28-ESR (high, moderate, low disease activity, and remission), then into two subgroups; group-1 (DAS-28≤3.2) and group-2 (DAS28>3.2). The predicting value of calprotectin for disease activity in patients with normal CRP was analysed with univariate and multivariate analysis and receiver operating characteristic curves. Results: Calprotectin levels were higher in RA patients than controls (96.3±45.9 ng/ml, 54.7±50.0 ng/ml, respectively; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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