Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and mendelian randomization study
| Autor: | Han-Qi Yang, James T. Elder, Zhi-Hua Yang, Peikuan Cong, Jiangwei Xia, Zhi-Min Ying, Ke-Qi Liu, Bin Wang, Mo-Chang Qiu, Rajan P. Nair, Zhao-Ming Ye, Pian-Pian Zhao, Wei-Yang Bai, Xiao-Wei Zhu, Jin-Qiu Zhao, Yan-Ping Zhu, Philip E. Stuart, Si-Rui Gai, Kaijing Mao, Lin Xu, Shu-Yang Xie, Bin Hu, Hou-Feng Zheng, Peng-Lin Guan, Yu-Ting Liao, Lam C. Tsoi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine medicine.medical_specialty Bone density business.industry Immunology Osteoporosis Confounding Arthritis medicine.disease Logistic regression General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Psoriatic arthritis 030104 developmental biology 0302 clinical medicine Rheumatology Psoriasis Internal medicine medicine Immunology and Allergy Risk factor business |
| Zdroj: | Ann Rheum Dis |
| Popis: | Objectives and methodsWith 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). The eBMD was derived from heel ultrasound measurement. And 4904 patients with psoriasis and 847 patients with PsA were included in final analysis. Mendelian randomisation (MR) approach was used to evaluate the causal effect between them.ResultsLower eBMD were observed in patients with PsA than in controls in both model0 (β-coefficient=−0.014, p=0.0006) and model1 (β-coefficient=−0.013, p=0.002); however, the association disappeared when conditioning on treatment with methotrexate or ciclosporin (model2) (β-coefficient=−0.005, p=0.28), mediation analysis showed that 63% of the intermediary effect on eBMD was mediated by medication treatment (pConclusionsThe effect of PsA on osteoporosis was secondary (eg, medication) but not causal. Under this hypothesis, psoriasis without arthritis was not a risk factor for osteoporosis. |
| Databáze: | OpenAIRE |
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