A single-day paradigm of self-regulated human cocaine administration
| Autor: | Jason I. Chen, P. Jatlow, Jane Wanyiri, Haleh Nadim, David Matuskey, Marc N. Potenza, Brian Pittman, Rt T. Malison, Pt T. Morgan, Zubin Bhagwagar, Ralitza Gueorguieva |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Subjective effects Clinical Biochemistry Blood Pressure Self Administration Cocaine related disorders Toxicology Biochemistry Article Cocaine-Related Disorders Behavioral Neuroscience Clinical Protocols Cocaine Cocaine users Heart Rate medicine Humans Psychiatry Adverse effect Infusion Pumps Biological Psychiatry Pharmacology Human studies Middle Aged Tolerability Emergency medicine Female Self-administration Timeout Psychology |
| Zdroj: | Pharmacology Biochemistry and Behavior. 103:95-101 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2012.08.009 |
| Popis: | Prior work by our group has shown the feasibility, safety, and validity of a multi-day, multi-dose paradigm of self-regulated cocaine administration in humans. The current work sought to consolidate these methods in a single-day design focused on reducing logistical complexity, decreasing research burden to human subjects, and increasing suitability for medication development designs. Methods: Eleven experienced cocaine users participated in a 6-hour, single-day design, consisting of one safety/eligibility and three experimental cocaine periods (during which subjects were allowed to self-administer 8, 16, and 32 mg/70 kg cocaine doses under a fixed-ratio 1: 5 minute timeout schedule). Changes in cocaine-induced cardiovascular response, self-administration behavior, and subjective effects were assessed. Results: Procedures were well tolerated by participants, and no significant adverse events were noted. Significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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