| Autor: |
Changyun Cho, Dohoon Lee, Dabin Jeong, Sun Kim, Myung Kyum Kim, Sathiyaraj Srinivasan |
| Rok vydání: |
2023 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-2474193/v1 |
| Popis: |
To respond to the external environmental changes for survival, bacteria regulates expression of a number of genes including transcription factors (TFs). To characterize complex biological phenomena, a biological system-level approach is necessary. Here we utilized six computational biology methods to infer regulatory network and to characterize underlying biologically mechanisms relevant to radiation-resistance. In particular, we inferred gene regulatory network (GRN) and operons of radiation-resistance bacterium Spirosoma montaniterrae DY10$$^T$$ T and identified the major regulators for radiation-resistance. Our results showed that DNA repair and reactive oxygen species (ROS) scavenging mechanisms are key processes and Crp/Fnr family transcriptional regulator works as a master regulatory TF in early response to radiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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