Microbubble Agents: New Directions
| Autor: | Thierry Bettinger, Eleanor Stride, Samir Cherkaoui, Guillaume Lajoinie, Michel Versluis, Tim Segers, Mark A. Borden |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Acoustics and Ultrasonics
Computer science Ultrasonic Therapy Microfluidics Biophysics Contrast Media Nanotechnology 02 engineering and technology 010402 general chemistry Multimodal Imaging 01 natural sciences Tissue penetration Theranostic Nanomedicine Drug Delivery Systems Animals Humans Radiology Nuclear Medicine and imaging Nanodroplets Ultrasonography Microbubbles Radiological and Ultrasound Technology Cavitation nuclei 22/2 OA procedure Ultrasound contrast agents 021001 nanoscience & nanotechnology Superresolution 0104 chemical sciences Theranostic Novel agents Drug delivery Imaging technology 0210 nano-technology |
| Zdroj: | Ultrasound in Medicine & Biology. 46:1326-1343 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2020.01.027 |
| Popis: | Microbubble ultrasound contrast agents have now been in use for several decades and their safety and efficacy in a wide range of diagnostic applications have been well established. Recent progress in imaging technology is facilitating exciting developments in techniques such as molecular, 3-D and super resolution imaging and new agents are now being developed to meet their specific requirements. In parallel, there have been significant advances in the therapeutic applications of microbubbles, with recent clinical trials demonstrating drug delivery across the blood-brain barrier and into solid tumours. New agents are similarly being tailored toward these applications, including nanoscale microbubble precursors offering superior circulation times and tissue penetration. The development of novel agents does, however, present several challenges, particularly regarding the regulatory framework. This article reviews the developments in agents for diagnostic, therapeutic and "theranostic" applications; novel manufacturing techniques; and the opportunities and challenges for their commercial and clinical translation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|