Results of neoadjuvant chemo(radio)therapy and resection for stage IIIA non-small cell lung cancer in The Netherlands
Autor: | Ronald A M Damhuis, Pieter J M Joosten, Houke M. Klomp, Egbert F. Smit, Judi N.A. van Diessen, José Belderbos, Joop A de Langen, Koen J. Hartemink, A. A. F. A. Veenhof |
---|---|
Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Adolescent medicine.medical_treatment Stage IIIA Non-Small Cell Lung Cancer Patient characteristics 030218 nuclear medicine & medical imaging Resection Young Adult 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Stage IIIA NSCLC medicine Humans Radiology Nuclear Medicine and imaging Registries Stage (cooking) Pneumonectomy Neoadjuvant therapy Aged Neoplasm Staging Netherlands Aged 80 and over business.industry Hematology General Medicine Middle Aged Neoadjuvant Therapy Cancer registry Survival Rate Treatment Outcome Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Female Radiology business Chemoradiotherapy |
Zdroj: | Acta Oncologica, 59(7), 748-752. TAYLOR & FRANCIS LTD |
ISSN: | 1651-226X 0284-186X |
DOI: | 10.1080/0284186x.2020.1757150 |
Popis: | Introduction: Concurrent chemoradiotherapy remains the main treatment strategy for patients with stage IIIA non-small cell lung cancer (NSCLC); stage cT3N1 or cT4N0-1 may be eligible for surgery and potentially resectable stage IIIA (N2) NSCLC for neoadjuvant therapy followed by resection. We evaluated treatment patterns and outcomes of patients with stage IIIA NSCLC in The Netherlands. Material and Methods: Primary treatment data of patients with clinically staged IIIA NSCLC between 2010 and 2016 were extracted from The Netherlands Cancer Registry. Patient characteristics were tabulated and 5-year overall survival (OS) was calculated and reported. Results: In total, 9,591 patients were diagnosed with stage IIIA NSCLC. Of these patients, 41.3% were treated with chemoradiotherapy, 11.6% by upfront surgery and 428 patients (4.5%) received neoadjuvant treatment followed by resection. The 5-year OS was 26% after chemoradiotherapy, 40% after upfront surgery and 54% after neoadjuvant treatment followed by resection. Clinical over staging was seen in 42.3% of the patients that were operated without neoadjuvant therapy. Conclusion: In The Netherlands, between 2010 and 2016, 4.5% of patients with stage IIIA NSCLC were selected for treatment with neoadjuvant therapy followed by resection. The 5-year OS in these patients exceeded 50%. However, the outcome might be overestimated due to clinical over staging. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |