Long-Term Depression Learning in Spinal Cord Networks
| Autor: | Karen Therrien, Paul K. LaFosse, Zachary Baker, Abdul Noor, Nathalia Peixoto |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neurons Neuroprosthetics Nerve net Long-Term Synaptic Depression Action Potentials Stimulation Biology Spinal cord Electronic mail 03 medical and health sciences Electrophysiology Mice 030104 developmental biology medicine.anatomical_structure Spinal Cord medicine Animals Nerve Net Long-term depression Neuroscience Microelectrodes |
| Zdroj: | EMBC |
| ISSN: | 2694-0604 |
| Popis: | Investigating learning in networks of spinal cord neurons can provide insight into the dynamics of connectivity in human spinal cords. It may also hold implications for developing neural prosthetics and neurocomputers. Culturing neural networks on microelectrode arrays (MEAs) allows for the repeated observation and stimulation of electrophysiological activity in vitro. Here we used MEAs to demonstrate learning in networks of spinal cord neurons. This was done by exposing E17 mouse spinal cord cultures to high frequency artificial spike trains, or tetanization. Unexpectedly, when comparing the networks’ responses to low-frequency probing stimulations before and after tetanization, the cultures were found to demonstrate long-term depression (LTD). LTD was most significantly observed between 500–1000 ms after low-frequency probing. These results indicate that periodic high-frequency excitation of spinal cord networks can result in decreased synaptic efficacy. |
| Databáze: | OpenAIRE |
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