Impact of a Measles and Rubella Vaccination Campaign on Seroprevalence in Southern Province, Zambia
| Autor: | Francis Dien Mwansa, Andrea C. Carcelen, William J. Moss, Kalumbu H. Matakala, Gina Mulundu, Mwaka Monze, Innocent Chilumba, Kyla Hayford, Simon Mutembo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Measles Vaccine Zambia Antibodies Viral Measles Rubella Herd immunity Young Adult Seroepidemiologic Studies Immunity Virology parasitic diseases medicine Humans Seroprevalence Rubella Vaccine Young adult Child Immunization Programs business.industry Vaccination Infant Newborn Infant virus diseases Articles Middle Aged medicine.disease Confidence interval Infectious Diseases Child Preschool Female Parasitology business Demography |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.20-1669 |
| Popis: | Zambia conducted a measles and rubella (MR) vaccination campaign targeting children 9 months to younger than 15 years of age in 2016. This campaign was the first introduction of a rubella-containing vaccine in Zambia. To evaluate the impact of the campaign, we compared the MR seroprevalence estimates from serosurveys conducted before and after the campaign in Southern Province, Zambia. The measles seroprevalence increased from 77.8% (95% confidence interval [CI], 73.2–81.9) to 96.4% (95% CI, 91.7–98.5) among children younger than 15 years. The rubella seroprevalence increased from 51.3% (95% CI, 45.6–57.0) to 98.3% (95% CI, 95.5–99.4). After the campaign, slightly lower seroprevalence remained for young adults 15 to 19 years old, who were not included in the campaign because of their age. These serosurveys highlighted the significant impact of the vaccination campaign and identified immunity gaps for those beyond the targeted vaccination age. Continued monitoring of population immunity can signal the need for future targeted vaccination strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|