Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus
| Autor: | Samuel Katsuyuki Shinjo, Claudia Salvini de Almeida, Márcio Veronesi Fukuda, Simone Chinwa Lo |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Comorbidity Skin Diseases Vascular Serology Sex Factors Rheumatology Internal medicine Humans Lupus Erythematosus Systemic Medicine Longitudinal Studies Retrospective Studies Lupus erythematosus biology business.industry Retrospective cohort study General Medicine medicine.disease Dermatology Antibodies Antinuclear Immunology biology.protein Female Antibody business Vasculitis Brazil Anti-SSA/Ro autoantibodies |
| Zdroj: | Clinical Rheumatology. 28:301-304 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s10067-008-1043-5 |
| Popis: | Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with various clinical and serological manifestations. Previous studies have shown the association of SLE and anti-Ro antibody with a series of clinical manifestations. We investigated this association in Brazilian patients with SLE. Five hundred and nine consecutive patients who fulfilled the revised American College of Rheumatology criteria for the SLE were enrolled in the study from June to December 2007. All patients were from our Service of Rheumatology, School of Medicine, University of São Paulo, Brazil. Frequencies of a series of laboratorial and clinical manifestations were calculated. Anti-Ro antibody was associated to anti-La antibody, female, and cutaneous vasculitis. In multivariate analysis, patients with anti-Ro antibody has 1.63 (95% CI 1.07-2.50) more risk to develop cutaneous vasculitis than patients without this antibody. Our data have demonstrated that anti-Ro antibody is an independent useful serologic marker for cutaneous vasculitis. |
| Databáze: | OpenAIRE |
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