Skeletal Muscle Mass Index Is Positively Associated With Bone Mineral Density in Hemodialysis Patients
| Autor: | Tatsuya Kamimura, Tadanao Kobayashi, Yusaku Bandai, Susumu Ookawara, Hidenori Sanayama, Sojiro Imai, Masatoshi Yasuda, Yasushi Ohnishi, Mitsutoshi Shindo, Satoshi Kiryu, Yoshiyuki Morishita, Kaoru Tabei, Yuri Hamashima, Kiyonori Ito, Noriko Wada, Mariko Fueki, Hideo Kakuda, Yutaka Hibino |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Osteoporosis 030232 urology & nephrology Urology 030209 endocrinology & metabolism sarcopenia 03 medical and health sciences Grip strength 0302 clinical medicine medicine Original Research Femoral neck Bone mineral osteosarcopenia lcsh:R5-920 hemodialysis business.industry General Medicine medicine.disease musculoskeletal system osteoporosis medicine.anatomical_structure skeletal muscle mass index Sarcopenia Medicine business bone mineral density lcsh:Medicine (General) Bioelectrical impedance analysis Body mass index Kidney disease |
| Zdroj: | Frontiers in Medicine, Vol 7 (2020) Frontiers in Medicine |
| DOI: | 10.3389/fmed.2020.00187/full |
| Popis: | Background: Patients with chronic kidney disease (CKD) are at risk for bone loss and sarcopenia because of associated mineral and bone disorders (MBD), malnutrition, and chronic inflammation. Both osteoporosis and sarcopenia are associated with a poor prognosis; however, few studies have evaluated the relationship between muscle mass and bone mineral density (BMD) in hemodialysis (HD) patients. The present study examined the association between skeletal muscle mass index (SMI) and BMD in the lumbar spine and femoral neck in HD patients. Methods: Fifty HD patients (mean age, 69 ± 10 years; mean HD duration, 9.0 ± 8.8 years) in Minami-Uonuma City Hospital were evaluated. BMD was measured by dual-energy X-ray absorptiometry, and SMI was measured by bioelectrical impedance analysis (InBodyTM) after HD. The factors affecting lumbar spine and femoral neck BMD were investigated, and multivariate analysis was performed. Results: In simple linear regression analysis, the factors that significantly affected the lumbar spine BMD were sex, presence of hypertension, presence of diabetes mellitus, body mass index, triglyceride level, grip strength, and SMI; the factors that significantly affected the femoral neck BMD were sex, HD duration, serum creatinine level, tartrate-resistant acid phosphatase 5b level, undercarboxylated osteocalcin (ucOC) level, N-terminal propeptide of type I procollagen level, grip strength, and SMI. In multivariate analysis, SMI (standardized coefficient: 0.578) was the only independent factor that affected the lumbar spine BMD; the independent factors that affected the femoral neck BMD were SMI (standardized coefficient: 0.468), ucOC (standardized coefficient: −0.366) and sex (standardized coefficient: 0.231). Conclusion: SMI was independently associated with the BMD in the lumbar spine and femoral neck in HD patients. The preservation of skeletal muscle mass could be important to prevent BMD decrease in HD patients, in addition to the management of CKD-MBD. |
| Databáze: | OpenAIRE |
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