Magnetic Resonance Assessment of Aortic Pulse Wave Velocity, Aortic Distensibility, and Cardiac Function in Uncomplicated Type 2 Diabetes Mellitus
| Autor: | Jeroen J. Bax, Hildo J. Lamb, Rutger W. van der Meer, Albert de Roos, Jos J.M. Westenberg, Michaela Diamant, Joost Doornbos |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Diastole Aorta Thoracic Ventricular Dysfunction Left Internal medicine medicine.artery Ascending aorta medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Pulse wave velocity Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Healthy subjects Type 2 Diabetes Mellitus Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Diabetes Mellitus Type 2 Case-Control Studies Pulsatile Flow Linear Models cardiovascular system Arterial stiffness Cardiology Female Vascular Resistance Cardiology and Cardiovascular Medicine business Blood Flow Velocity circulatory and respiratory physiology |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance. 9:645-651 |
| ISSN: | 1097-6647 |
| DOI: | 10.1080/10976640601093703 |
| Popis: | Type 2 diabetes mellitus (DM2) may augment arterial stiffening and thereby modulates left ventricular (LV) function. Cardiovascular magnetic resonance (CMR) is well suited to assess aortic pulse wave velocity (PWV) and aortic distensibility, both markers of arterial stiffness, without the use of geometric assumptions. Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility in patients with DM2 using MR.Fourteen patients with well controlled, uncomplicated DM2, and 16 age and gender matched healthy subjects were included. PWV was calculated based on MR velocity mapping at two predefined aortic locations. Aortic distensibility was measured in the mid ascending aorta. LV volumes were measured by fast gradient-echo imaging to assess systolic function. Furthermore, mitral inflow was measured by MR velocity mapping to assess diastolic LV function.Mean PWV was higher in patients as compared to healthy subjects (6.83 +/- 1.60 m/s vs. 5.65 +/- 0.75 m/s, p0.05). This difference was independent of blood pressure. PWV correlated significantly (p0.05) with fasting plasma glucose and insulin levels. Aortic distensibility was lower in patients as compared to healthy subjects (4.50 x 10(- 3)+/- 2.24 x 10(- 3) mmHg(- 1) vs. 7.42 x 10(- 3)+/- 3.34 x 10(- 3) mmHg(- 1), p0.05). Distensibility correlated negatively with PWV and positively with LV diastolic function (p0.05).A combined CMR assessment of aortic PWV, aortic distensibility, and heart function reveals abnormal PWV and distensibility in patients with DM2, independent of blood pressure. Furthermore, aortic distensibility correlates with diastolic left ventricular function. |
| Databáze: | OpenAIRE |
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