The Schistosoma japonicum genome reveals features of host–parasite interplay
| Autor: | Genfeng Zhu, Y.S. Wang, Kai Wang, Daniel G. Brown, Zheng Feng, Zhi-Qin Wang, Jie Yan, Bin Xu, Hui Kang, Shiyin Pu, Huai-Dong Song, Li Wang, Biyun Wang, Bofei Wang, Lei Jin, Paul J. Brindley, Tonghai Dou, Brona Brejová, Guoping Zhao, Yang Zhong, Tomas Vinar, Jie Chen, Wenyi Gu, Donald P. McManus, Jing Guo, David Blair, Sai-Juan Chen, David J. Miller, Jing Wang, Yijun Ruan, Jun Wang, Xiaoyun Chen, Jun Yu, Yucheng Huang, Jie Zhou, Ze-Guang Han, Yangyi Chen, Huanming Yang, Gang Lu, Huajun Zheng, Qiuping Hu, Lijun Wang, Wei Hu, Feng Liu, Yan Zhou, Zhiwei Cao, Xue-Nian Xu, Bo Zhang, Matthew Beriman, Zhen Huang, Chuan Ju, Yixue Li, Shengyue Wang, Shuang-Xi Ren, Lin Tao, Wei Zhang, Qin-Hua Zhang, Zhu Chen, Yuan Zhang, Shuting Chen, Ke Jin, Chia-Lin Wei, Zemin Ning, Xiang-Lin Zhang, Lei Zhang, Xinyan Lv, Wei Huang, Ming Li, Masami Hasegawa |
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| Rok vydání: | 2009 |
| Předmět: |
Systems biology
Molecular Sequence Data Endocrine System Genomics Schistosomiasis Proteomics Nervous System Genome Schistosoma japonicum Article Host-Parasite Interactions Evolution Molecular Gene Duplication medicine Animals Genes Helminth Phylogeny Genetics Genome Helminth Flatworm Multidisciplinary biology biology.organism_classification medicine.disease Protein Structure Tertiary Immune System Inflammation Mediators Functional genomics Peptide Hydrolases Signal Transduction |
| Zdroj: | Nature. 460:345-351 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature08140 |
| Popis: | Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm, which is the first reported for any flatworm, indeed for the superphylum Lophotrochozoa. The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signaling pathways for growth, development and maturation. Having a complex nervous system and a well developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissues of its intermediate and mammalian hosts. Numerous proteinases, including cercarial elastase, are implicated in mammalian skin penetration and haemoglobin degradation. The genomic information will serve as a valuable platform to facilitate development of new interventions for schistosomiasis control. |
| Databáze: | OpenAIRE |
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