Dual-Axis Confocal Microscopy for Point-of-Care Pathology
| Autor: | Jonathan T. C. Liu, Linpeng Wei, Chengbo Yin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Optical sectioning Confocal 02 engineering and technology Article Atomic and Molecular Physics and Optics Dual axis confocal law.invention 020210 optoelectronics & photonics Confocal microscopy law Microscopy 0202 electrical engineering electronic engineering information engineering Miniaturization Electrical and Electronic Engineering Preclinical imaging Biomedical engineering Point of care |
| Zdroj: | IEEE Journal of Selected Topics in Quantum Electronics. 25:1-10 |
| ISSN: | 1558-4542 1077-260X |
| DOI: | 10.1109/jstqe.2018.2854572 |
| Popis: | Dual-axis confocal (DAC) microscopy is a high-resolution optical imaging modality that utilizes simple low-numerical-aperture (NA) beams to achieve effective optical sectioning and superior image contrast in biological tissues. In addition to providing enhanced imaging performance, the DAC architecture provides certain advantages for miniaturization, facilitating the development of endoscopic, and handheld systems for in vivo imaging. This article reviews the principles of DAC microscopy, highlighting the differences between DAC microscopy and conventional confocal microscopy. Several technical variations of DAC microscopy will be surveyed, as well as clinical DAC microscopy prototypes that have been developed as noninvasive real-time alternatives to conventional biopsy and histopathology. |
| Databáze: | OpenAIRE |
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