Syndrome of inappropriate antidiuretic hormone secretion in a case of olfactory neuroblastoma without anti-diuretic hormone immunoreactivity: A case report and review of the literature
| Autor: | Takafumi Nakano, Ryuji Yasumatsu, Fumi Sawada, Midori Okabe, Torahiko Nakashima, Satoru Kodama, Shinsuke Hiramatsu, Takashi Nakagawa, Junichi Motoshita, Akihiro Tamae, Hideki Shiratsuchi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Nasal cavity Pathology medicine.medical_specialty medicine.medical_treatment Nose Neoplasms Tumor resection Synaptophysin Esthesioneuroblastoma Olfactory Inappropriate ADH Syndrome 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography Biopsy Humans Medicine 030223 otorhinolaryngology medicine.diagnostic_test Olfactory Neuroblastoma business.industry Cancer Chemoradiotherapy General Medicine medicine.disease CD56 Antigen Otorhinolaryngologic Surgical Procedures medicine.anatomical_structure Otorhinolaryngology Phosphopyruvate Hydratase 030220 oncology & carcinogenesis Syndrome of inappropriate antidiuretic hormone secretion Chromogranin A Female Surgery Nasal Cavity Diuretic Tomography X-Ray Computed business Hormone |
| Zdroj: | Auris Nasus Larynx. 44:771-774 |
| ISSN: | 0385-8146 |
| DOI: | 10.1016/j.anl.2016.11.012 |
| Popis: | Olfactory neuroblastoma (ONB) is a relatively rare nasal or paranasal malignant tumor. This tumor is rarely accompanied by paraneoplastic syndromes such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Here, we report a 31-year-old female with histologically confirmed ONB who had been diagnosed with SIADH three years prior. She was treated with surgery followed by concurrent chemoradiotherapy. SIADH resolved immediately after surgical tumor resection. Immunohistochemically, both biopsy and resected specimens from the nasal cavity had been negative for ADH. Although extremely rare, ONB may be associated with SIADH, and the possibility of this cancer should be taken into account during the follow-up of idiopathic SIADH. |
| Databáze: | OpenAIRE |
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