Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes
| Autor: | Samir Z. Zard, Jean-Pierre Vors, Vincent L. Revil-Baudard |
|---|---|
| Přispěvatelé: | Laboratoire de synthèse organique (DCSO), École polytechnique (X)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bayer S.A.S |
| Rok vydání: | 2018 |
| Předmět: |
[CHIM.ORGA]Chemical Sciences/Organic chemistry
010405 organic chemistry Organic Chemistry Alkyl radicals 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Chemical space 0104 chemical sciences chemistry.chemical_compound chemistry Surface modification Xanthate Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters Organic Letters, American Chemical Society, 2018, 20 (12), pp.3531-3535. ⟨10.1021/acs.orglett.8b01299⟩ |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | International audience; The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work provides a synthetic tool for efficiently exploring the chemical space by allowing late-stage diversification with a high tolerance toward functional groups. |
| Databáze: | OpenAIRE |
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