Long-Term Cortisol Exposure and Associations With Height and Comorbidities in Turner Syndrome
| Autor: | Yolanda B. de Rijke, Erica L T van den Akker, Mesut Savas, Ramon H. M. Dykgraaf, Laura C. G. de Graaff, Jolien W. Roos-Hesselink, Vincent L. Wester, Elisabeth F.C. van Rossum, Arianne B. Dessens |
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| Přispěvatelé: | Internal Medicine, Obstetrics & Gynecology, Pediatrics, Cardiology, Child and Adolescent Psychiatry / Psychology, Clinical Chemistry |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry Population 030209 endocrinology & metabolism Context (language use) Biochemistry Short stature 03 medical and health sciences 0302 clinical medicine Endocrinology Quality of life Internal medicine Turner syndrome medicine education education.field_of_study business.industry Biochemistry (medical) Anthropometry medicine.disease Premature ovarian failure medicine.symptom business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 104(9), 3859-3867. Endocrine Society |
| ISSN: | 0021-972X |
| Popis: | ContextTurner syndrome (TS) usually manifests in traits as short stature and premature ovarian failure. Many patients also have an increased risk of cardiometabolic disorders and psychological distress, which are features that overlap with those of a prolonged state of hypercortisolism.ObjectiveTo investigate whether TS is associated with increased long-term cortisol concentrations as measured in scalp hair and whether these are linked to cardiometabolic and psychological parameters.DesignProspective observational case-control study.SettingAcademic outpatient TS expertise center.ParticipantsFifty-five patients with TS (53% 45,X karyotype), and 110 age-matched female community control subjects from the general population–based Lifelines cohort study.Main Outcome MeasuresHair cortisol concentrations (HCC), anthropometrics, biochemical parameters, and psychological questionnaires for perceived stress (Perceived Stress Scale–14), fatigue (Checklist Individual Strength–20), and health-related quality of life (RAND-36).ResultsCompared with control subjects, patients with TS had higher HCC [geometric mean, 3.51 pg/mg (95% CI, 2.64 to 4.65) vs 2.39 pg/mg (2.13 to 2.68); P = 0.003] and a worse cardiometabolic profile in terms of fasting glucose, and triglycerides. HCC was only associated with total cholesterol levels (standardized β = 0.294; P = 0.047) and was not associated with the psychological outcomes. A higher HCC was inversely associated with height only in patients with TS (standardized β = −0.307; P = 0.023).ConclusionPatients with TS are chronically exposed to higher cortisol levels, which is associated with short stature and increased total cholesterol levels, and potentially contributes to the known elevated cardiovascular disease risk. |
| Databáze: | OpenAIRE |
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