Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies
| Autor: | Xiaoyuan Du, Wen-Yuan Gao, Xueying Liu, Guanying Han |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Gerontology medicine.medical_specialty Pharmacy tea consumption Cochrane Library Lower risk 03 medical and health sciences 0302 clinical medicine Risk Factors Environmental health Epidemiology medicine Humans 030212 general & internal medicine Aged Aged 80 and over dose-response Tea business.industry Odds ratio Confidence interval Observational Studies as Topic Oncology Meta-analysis cognitive disorders Female Observational study Cognition Disorders business 030217 neurology & neurosurgery Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.17429 |
| Popis: | // Xueying Liu 1, 2 , Xiaoyuan Du 3 , Guanying Han 4 and Wenyuan Gao 1 1 School of Pharmaceutical Science and Technology, Tianjin University, Nankai District, Tianjin 300072, China 2 Department of Pharmacy, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China 3 Department of Pathology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China 4 Department of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China Correspondence to: Wenyuan Gao, email: gaowenyvip@163.com Keywords: tea consumption, cognitive disorders, dose-response, meta-analysis Received: February 15, 2017 Accepted: March 29, 2017 Published: April 26, 2017 ABSTRACT Background: The epidemiological evidence for a dose-response relationship between tea consumption and risk of cognitive disorders is sparse. The aim of the study was to summarize the evidence for the association of tea consumption with risk of cognitive disorders and assess the dose-response relationship. Methods: We searched electronic databases of Pubmed, Embase, and Cochrane Library (from 1965 to Jan 19, 2017) for eligible studies that published in the international journals. A random-effects model was used to pool the most adjusted odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Results: Seventeen studies involving 48,435 participants were included in our study. The meta-analysis showed that a higher tea consumption was associated with a significant reduction in the risk of cognitive disorders (OR=0.73, 95% CI: 0.65-0.82). When considering the specific types of tea consumption, the significantly inverse association is only found in green tea consumption (OR=0.64, 95% CI: 0.53-0.77) but not in black/oolong tea consumption (OR=0.75, 95% CI: 0.55-1.01). Dose-response meta-analysis indicated that tea consumption is linearly associated with a reduced risk of cognitive disorders. An increment of 100 ml/day, 300 ml/day, and 500 ml/day of tea consumption was associated with a 6% (OR=0.94, 95% CI: 0.92-0.96), 19% (OR=0.81, 95% CI: 0.74-0.88), and 29% (OR=0.71, 95% CI: 0.62-0.82) lower risk of cognitive disorders. Conclusions: Tea consumption is inversely and linearly related to the risk of cognitive disorders. More studies are needed to further confirm our findings. |
| Databáze: | OpenAIRE |
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