Tumor-associated macrophages: an accomplice in solid tumor progression
| Autor: | Longlong Gong, Haocai Chang, Yibing Chen, Wei Du, Zhengzhi Zou, Yucen Song |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Therapeutic target
Angiogenesis Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry lcsh:Medicine Review Metastasis Mice Invasion stomatognathic system Neoplasms Tumor Microenvironment medicine Animals Humans Pharmacology (medical) skin and connective tissue diseases Molecular Biology Tumor growth Migration Chemotherapy and radiotherapy resistance Tumor microenvironment Chemotherapy Neovascularization Pathologic Solid tumor business.industry Macrophages Monocyte Tumor-associated macrophages Biochemistry (medical) lcsh:R Immunosuppression Cell Biology General Medicine medicine.disease Radiation therapy medicine.anatomical_structure Cancer cell Disease Progression Cancer research business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-13 (2019) Journal of Biomedical Science |
| ISSN: | 1423-0127 |
| Popis: | In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. We also specifically focus on the role of TAMs in promoting tumor growth, enhancing cancer cells resistance to chemotherapy and radiotherapy, promoting tumor angiogenesis, inducing tumor migration and invasion and metastasis, activating immunosuppression. In addition, we discuss TAMs can be used as therapeutic targets of solid tumor in clinics. The therapeutic strategies include clearing macrophages and inhibiting the activation of TAMs, promoting macrophage phagocytic activity, limiting monocyte recruitment and other targeted TAMs therapies. |
| Databáze: | OpenAIRE |
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