Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population
| Autor: | V Vazgiourakis, Maria I. Zervou, George N. Goulielmos, Eva Choustoulaki, Eleni Krasoudaki, Amalia Raptopoulou, Dimitrios T. Boumpas, Herakles Kritikos, Prodromos Sidiropoulos, Eleni Petraki |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Genotype Immunology Population Biology Polymorphism Single Nucleotide Arthritis Rheumatoid Gene Frequency Polymorphism (computer science) Humans Immunology and Allergy SNP Genetic Predisposition to Disease Allele education STAT4 Alleles Aged Genetic association Genetics education.field_of_study Greece General Medicine Odds ratio Middle Aged STAT4 Transcription Factor TNF Receptor-Associated Factor 1 Case-Control Studies Female |
| Zdroj: | Human Immunology. 69:567-571 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2008.06.006 |
| Popis: | Summary Rheumatoid arthritis (RA) is a multifactorial disease that is increasing in incidence worldwide. It is associated with a complex mode of inheritance, with many genes being involved in the development and progression of the disease. Genome-wide association studies in different populations have recently revealed a significant association between a TRAF1/C5 and a STAT4 polymorphism and the development of RA. In the present study we performed a case-control study in the population of the island of Crete, Greece, aiming to replicate the former findings in a genetically homogeneous cohort of patients. We found that mutated allele A or genotypes A/A and G/A of the TRAF1/C5 rs10818488 SNP were more common in individuals with RA than in control individuals (odds ratio [OR] = 1.7, 95% confidence interval [CI] = 1.35–2.15, and OR = 2.22, 95% CI = 1.61–3.05, respectively). Similarly, mutated allele T or genotypes T/T and G/T of the STAT4 rs7574865 SNP were also associated with susceptibility to RA (OR = 1.9, 95% CI = 1.46–2.50, and OR = 2.37, 95% CI 1.73–2.25, respectively). Thus, we conclude that mutant alleles or genotypes of both polymorphisms examined are associated with the development of RA in our population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect