Overexpression of connexin 26 in carcinoma of the pancreas
| Autor: | Masataka Ikeda, Hiroshi Nojima, Mitsugu Sekimoto, Morito Monden, Masakazu Miyake, Keizo Dono, Naganori Kyo, Yuichiro Doki, Motokazu Terayama, Chew Yee Ngan, Koji Ezumi, Yutaka Takeda, Hirofumi Yamamoto, Ichiro Takemasa |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Pancreatic disease Colorectal cancer Biology Connexins Pancreatic cancer otorhinolaryngologic diseases medicine Carcinoma Humans Gastrointestinal cancer Gastrointestinal Neoplasms Cancer General Medicine medicine.disease Immunohistochemistry Up-Regulation Connexin 26 Pancreatic Neoplasms medicine.anatomical_structure Oncology Hepatocellular carcinoma Pancreas |
| Zdroj: | Oncology reports. 19(3) |
| ISSN: | 1021-335X |
| Popis: | Contrary to the previously purported role of gap junction (GJ) associated-protein connexin 26 (Cx26) as a tumor suppressor, increased expression of Cx26 has recently been demonstrated in several human malignancies. Surprisingly, this high expression is reportedly related to poor prognosis in squamous cell lung carcinoma and breast cancer. In this study, we examined levels of Cx26 in various human gastrointestinal (GI) carcinomas, with a focus on pancreatic carcinomas, using immunohistochemistry. Many GI carcinomas displayed abundant Cx26 expression, predominantly in the cytoplasm. Cx26 was detected in 5/8 gastric cancers (62.5%), 6/8 squamous cell carcinomas of the esophagus (75.0%), 7/8 pancreatic cancers (87.5%) and 7/8 colon cancer cases (87.5%). However, Cx26 expression was not present in hepatocellular carcinoma (HCC, 0/8). Extensive immunohistochemical examination was performed on pancreatic carcinomas, revealing strong expression of Cx26 protein in 30/43 cases (70%), weak expression in 6/43 (14%) and no expression in 7/43 (16%). The present study demonstrated up-regulated Cx26 expression in a considerable percentage of GI carcinomas, with the exception of HCC. Our findings suggest that Cx26 may be involved in some of the malignant processes of GI cancers, and especially in pancreatic carcinomas. |
| Databáze: | OpenAIRE |
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