Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo
| Autor: | Francesco Ferraguti, Thomas C.M. Bienvenu, Marco Capogna, Daniela Busti, Peter J. Magill |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Action Potentials/physiology Calbindins Interneuron Nerve net Neuroscience(all) Hippocampus/metabolism Hippocampus Action Potentials Sensory system Axons/metabolism Hippocampal formation Amygdala Article Rats Sprague-Dawley S100 Calcium Binding Protein G Interneurons medicine Animals Nerve Net/physiology Parvalbumins/metabolism Theta Rhythm Theta Rhythm/physiology General Neuroscience musculoskeletal neural and ocular physiology Axons Rats medicine.anatomical_structure Parvalbumins nervous system GABAergic Nerve Net Interneurons/metabolism Psychology Amygdala/metabolism S100 Calcium Binding Protein G/metabolism Neuroscience Basolateral amygdala |
| Zdroj: | Bienvenu, T C M, Busti, D, Magill, P J, Ferraguti, F & Capogna, M 2012, ' Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo ', Neuron, vol. 74, no. 6, pp. 1059-74 . https://doi.org/10.1016/j.neuron.2012.04.022 Neuron |
| DOI: | 10.1016/j.neuron.2012.04.022 |
| Popis: | Summary Neuronal synchrony in the basolateral amygdala (BLA) is critical for emotional behavior. Coordinated theta-frequency oscillations between the BLA and the hippocampus and precisely timed integration of salient sensory stimuli in the BLA are involved in fear conditioning. We characterized GABAergic interneuron types of the BLA and determined their contribution to shaping these network activities. Using in vivo recordings in rats combined with the anatomical identification of neurons, we found that the firing of BLA interneurons associated with network activities was cell type specific. The firing of calbindin-positive interneurons targeting dendrites was precisely theta-modulated, but other cell types were heterogeneously modulated, including parvalbumin-positive basket cells. Salient sensory stimuli selectively triggered axo-axonic cells firing and inhibited firing of a disctinct projecting interneuron type. Thus, GABA is released onto BLA principal neurons in a time-, domain-, and sensory-specific manner. These specific synaptic actions likely cooperate to promote amygdalo-hippocampal synchrony involved in emotional memory formation. Highlights ► Comprehensive definition of interneuron types of the basolateral amygdala ► Identification of the target subcellular domains of each cell type ► GABAergic cell-type-specific coding of hippocampal theta rhythm and sensory stimuli ► Axo-axonic interneurons are excited by salient sensory stimuli Bienvenu et al. provide a comprehensive characterization and in vivo recordings of basolateral amygdala interneurons. Their findings suggest that GABA is released onto BLA principal neurons in a time-, subcellular domain-, and sensory-dependent manner. |
| Databáze: | OpenAIRE |
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