Effect of palbociclib plus endocrine therapy on time to chemotherapy across subgroups of patients with hormone receptor‒positive/human epidermal growth factor receptor 2‒negative advanced breast cancer: Post hoc analyses from PALOMA-2 and PALOMA-3
| Autor: | Hope S, Rugo, Seock-Ah, Im, Anil A, Joy, Yaroslav, Shparyk, Janice M, Walshe, Bethany, Sleckman, Sherene, Loi, Kathy Puyana, Theall, Sindy, Kim, Xin, Huang, Eustratios, Bananis, Reshma, Mahtani, Richard S, Finn, Véronique, Diéras |
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| Rok vydání: | 2022 |
| Předmět: |
Progression -free survival
Clinical Trials and Supportive Activities Clinical Sciences Progression-free survival Evaluation of treatments and therapeutic interventions Breast Neoplasms Palbociclib General Medicine ErbB-2 Good Health and Well Being Clinical Research 6.1 Pharmaceuticals Antineoplastic Combined Chemotherapy Protocols Breast Cancer Public Health and Health Services Humans Chemotherapy Female Advanced breast cancer Surgery Oncology & Carcinogenesis Safety Fulvestrant Receptor Cancer |
| Zdroj: | The Breast. 66:324-331 |
| ISSN: | 0960-9776 |
| Popis: | BackgroundPrevious analyses from the PALOMA-2 and PALOMA-3 studies showed that palbociclib (PAL) plus endocrine therapy (ET) prolongs time to first subsequent chemotherapy (TTC) versus placebo (PBO) plus ET in the overall population of patients with hormone receptor‒positive/human epidermal growth factor receptor 2‒negative (HR+/HER2-) advanced breast cancer (ABC). Here, we evaluated TTC in relevant patient subgroups.MethodsThese post hoc analyses evaluated TTC by subgroup using data from 2 randomized, phase 3 studies of women with HR+/HER2- ABC. In PALOMA-2, postmenopausal patients previously untreated for ABC were randomized 2:1 to receive PAL (125mg/day, 3/1-week schedule) plus letrozole (LET; 2.5mg/day; n=444) or PBO plus LET (n=222). In PALOMA-3, premenopausal or postmenopausal patients whose disease had progressed after prior ET were randomized 2:1 to receive PAL (125mg/day, 3/1-week schedule) plus fulvestrant (FUL; 500mg; n=347) or PBO plus FUL (n=174).ResultsFirst subsequent chemotherapy was received by 35.5% and 56.2% in PALOMA-2 and PALOMA-3 after progression on palbociclib plus ET or placebo plus ET. Across all subgroups analyzed, the median progression-free survival (PFS) was longer in the PAL plus ET arm than the PBO plus ET arm. TTC was longer with PAL plus ET versus PBO plus ET across the same patient subgroups in both studies.ConclusionsAcross all subgroups, PAL plus ET versus PBO plus ET had longer median PFS and resulted in prolonged TTC in both the PALOMA-2 and PALOMA-3 studies. Pfizer Inc (NCT01740427, NCT01942135). |
| Databáze: | OpenAIRE |
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