Roles of noncoding RNAs in preeclampsia
Autor: | Lu Zhang, Ningxia Sun, Shiguo Liu, Shiting Qin |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
RNA Untranslated QH471-489 Review Biology Bioinformatics Polymorphism Single Nucleotide Preeclampsia Pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology lncRNA Pre-Eclampsia Pregnancy microRNA medicine Humans Clinical significance circRNA Epigenetics Protein Interaction Maps Noninvasive biomarkers Reproduction Obstetrics and Gynecology Gynecology and obstetrics Biomarker medicine.disease Non-coding RNA MicroRNAs 030104 developmental biology Reproductive Medicine 030220 oncology & carcinogenesis RG1-991 Biomarker (medicine) Female RNA Long Noncoding Developmental Biology |
Zdroj: | Reproductive Biology and Endocrinology : RB&E Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-20 (2021) |
ISSN: | 1477-7827 |
Popis: | Preeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal period. As the pathogenesis of PE is unclear, there are few specific remedies. Currently, the only way to eliminate the clinical symptoms is to terminate the pregnancy. Although noncoding RNA (ncRNA) was once thought to be the “junk” of gene transcription, it is now known to be widely involved in pathological and physiological processes, including pregnancy-related disorders. Moreover, there is growing evidence that the unbalanced expression of specific ncRNA is involved in the pathogenesis of PE. In the present review, we summarize the expression patterns of ncRNAs, i.e., microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), and the functional mechanisms by which they affect the development of PE, and examine the clinical significance of ncRNAs as biomarkers for the diagnosis of PE. We also discuss the contributions made by genetic polymorphisms and epigenetic ncRNA regulation to PE. In the present review, we wish to explore and reinforce the clinical value of ncRNAs as noninvasive biomarkers of PE. |
Databáze: | OpenAIRE |
Externí odkaz: |