Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis

Autor:	Sandro Antonio Pereira, Raquel de Vasconcellos Carvalhaes de Oliveira, Rosely Maria Zancopé-Oliveira, Ingeborg M. Langohr, Isabella Dib Ferreira Gremião, Cintia de Moraes Borba, Elaine Waite de Souza, Manoel Marques Evangelista de Oliveira, Camila Rocha da Cunha, Luisa Helena Monteiro de Miranda, Rodrigo Caldas Menezes
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male 0301 basic medicine medicine.medical_specialty Pathology Antifungal Agents Neutrophils Itraconazole 030106 microbiology lcsh:Medicine Mucous membrane of nose Cat Diseases Serology Lesion 03 medical and health sciences Feline Acquired Immunodeficiency Syndrome medicine Animals Lymphocytes lcsh:Science Immunodeficiency Skin Multidisciplinary CATS Sporotrichosis Coinfection business.industry Macrophages Sporothrix lcsh:R medicine.disease Host-Pathogen Interactions Cats Female Histopathology lcsh:Q medicine.symptom business medicine.drug
Zdroj:	Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
ISSN:	2045-2322
DOI:	10.1038/s41598-018-27447-5
Popis:	Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats coinfected with FIV/FeLV (n = 12) had a lower neutrophil count in the lesion. A high fungal load in skin lesions was linked to young age and treatment failure, as well as to a longer time of wound healing, poorly formed granulomas and fewer neutrophils, macrophages and lymphocytes in these lesions. These results indicate that itraconazole is effective, but nasal mucosal involvement, respiratory signs and high fungal loads in skin lesions are predictors of treatment failure that will assist in the development of better treatment protocols for cats.
Databáze:	OpenAIRE
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