Mutational specificity of the syn 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene

T and G --> C changes accounting for 42 and 21% of total base change mutations. The types of mutations found reflect the previously determined chemical preference of this reactive species for reaction with deoxyguanosine residues in DNA. -->

ISSN:	0304-3835
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2b73b27de5122048015e2f101c930f https://doi.org/10.1016/s0304-3835(96)04506-5
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....9a2b73b27de5122048015e2f101c930f
Autor:	Ronald G. Harvey, John Pataki, Anthony Dipple, John E. Page
Rok vydání:	1996
Předmět:	Cancer Research Mutation Base Sequence Chemistry Genetic Vectors Molecular Sequence Data Mutagenesis Epoxide Mutagen Transfection medicine.disease_cause Molecular biology Chrysenes chemistry.chemical_compound Oncology Biochemistry Carcinogens Mutagenesis Site-Directed medicine Deoxyguanosine sense organs Transversion Gene DNA
Zdroj:	Cancer Letters. 110:249-252
ISSN:	0304-3835
Popis:	The mutational specificity of the syn dihydrodiol epoxide of 5-methylchrysene in the supF gene of the pSP189 vector was examined. Transversion mutations at GC pairs predominated with G --> T and G --> C changes accounting for 42 and 21% of total base change mutations. The types of mutations found reflect the previously determined chemical preference of this reactive species for reaction with deoxyguanosine residues in DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2b73b27de5122048015e2f101c930f https://doi.org/10.1016/s0304-3835(96)04506-5 Zobrazit plný text záznamu Full Text from ScienceDirect