Effects of anabolic steroids and endurance exercise on cardiac performance
| Autor: | L. W. Gierke, M. T. C. Liang, F. N. Schwartz, P. Meneses, T. Glonek, D. J. Paulson, S. J. Kopp |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Anabolism medicine.medical_treatment Cardiac Volume Physical Exertion Physical Therapy Sports Therapy and Rehabilitation Physical exercise Injections Intramuscular Ventricular Function Left Contractility Placebos Rats Sprague-Dawley Anabolic Agents Endurance training Heart Rate Internal medicine medicine Ventricular Pressure Aerobic exercise Animals Nandrolone Orthopedics and Sports Medicine Treadmill business.industry Body Weight Heart Organ Size Myocardial Contraction Rats Endocrinology Nandrolone Decanoate Circulatory system Exercise Test Physical Endurance business Anabolic steroid |
| Zdroj: | International journal of sports medicine. 14(6) |
| ISSN: | 0172-4622 |
| Popis: | This study examined the effects of anabolic steroids and exhaustive endurance exercise, and the combination of both treatments on in vitro cardiac contractile function. Fifty-two male Sprague-Dawley rats were randomly assigned, in groups of 13, to one of the four groups: sedentary control (C), steroid-treated (ST), exercise-trained (E), and exercise plus steroid treated (E+S). Nandrolone decanoate was administered to the steroid-treated groups every 7-9 days during the 10 weeks study, while the C and E groups received glycerol injection on these occasions. The exercised rats ran on a treadmill wearing a collar weight (2-3% of body weight) for 50 min, 5 days a week. In vitro ventricular performance was assessed in isolated Langendorff perfused hearts in response to increasing left ventricular balloon volumes. Left ventricular +dP/dt, dP/dt at 60 mmHg developed pressure, tension time index, and Emax (slope of the pressure-volume curves) were significantly (p < 0.05) lowered in the E+S group, as compared to the C, E, or ST group. Meanwhile, the E group exhibited a higher (p < 0.05) left ventricular systolic pressure (LVSP) than the C and E+S groups. No significant differences in dP/dt/P, heart weight (wt), and heart wt to body wt ratio were detected among the four groups. Rats subjected to endurance exercise or anabolic steroid treatment alone exhibited no change in LV function.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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