Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents

Autor:	Ahmed S. Ismael, Noha H. Amin, Mohammed T. Elsaadi, Hamdy M. Abdel-Rahman
Rok vydání:	2022
Předmět:	Leukemia Molecular Structure Pyridines Organic Chemistry Hydrazones Antineoplastic Agents Biochemistry ErbB Receptors Molecular Docking Simulation Structure-Activity Relationship Cell Line Tumor Drug Design Drug Discovery Humans Drug Screening Assays Antitumor Molecular Biology Cell Proliferation
Zdroj:	Bioorganic Chemistry. 128:106042
ISSN:	0045-2068
DOI:	10.1016/j.bioorg.2022.106042
Popis:	Herein, the design, synthesis and mechanistic study of five series of imidazo[1,2-a]pyridines 8a-d, 9a-f, 11a-c, 12a-d and 14a-d as anticancer agents were discussed. The cytotoxicity of imidazo[1,2-a]pyridine derivatives was screened against NCI 60 cancer cell lines. The cytotoxicity of compounds 8b, 8c, 9e and 9f was then evaluated against leukemia K-562 cancer cell line and normal lung fibroblasts (WI38). The hydrazone derivatives 8b and 8c exhibited significant cytotoxic activities against the leukemia K-562 cancer cell line with good safety margins (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2a2d8b30f23978f786097ea74195b3 https://doi.org/10.1016/j.bioorg.2022.106042 Zobrazit plný text záznamu Full Text from ScienceDirect