The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Autor:	Timothy Burgess, Darci R. Smith, Anthony C. Fries, Anuradha Ganesan, Eric D Laing, Derek T Larson, Brian K. Agan, Emily C Samuels, Tahaniyat Lalani, Cristian Madar, Christopher J Colombo, Rupal M. Mody, Stephanie A Richard, Katrin Mende, Mark P Simons, David R. Tribble, Tida Lee, Sharon Chi, Christopher C. Broder, Rhonda E Colombo, Simon Pollett
Rok vydání:	2021
Předmět:	Microbiology (medical) 2019-20 coronavirus outbreak COVID-19 Vaccines Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Genotype Humans Medicine RNA Messenger 030212 general & internal medicine Live virus Vaccines Synthetic Messenger RNA Genetic diversity SARS-CoV-2 business.industry COVID-19 Genetic Variation Breakthrough infection Virology Phenotype Virus Shedding Infectious Diseases mRNA Vaccines business
Zdroj:	Clinical Infectious Diseases. 74:897-900
ISSN:	1537-6591 1058-4838
Popis:	Little is known about severe acute respiratory syndrome coronavirus 2 “vaccine-breakthrough” infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a294b052f3fb9d19186fac603841ace https://doi.org/10.1093/cid/ciab543 Zobrazit plný text záznamu