Clinical and anatomopathological aspects of patients with hantavirus cardiopulmonary syndrome in Uberaba, Minas Gerais, Brazil
| Autor: | Adilha Misson Rua Micheletti, Mário-León Silva Vergara, João Paulo Vieira dos Santos, Sheila Jorge Adad |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male myalgia medicine.medical_specialty Adolescent Pleural effusion RC955-962 030231 tropical medicine Autopsy Severity of Illness Index Gastroenterology Pericardial effusion 03 medical and health sciences 0302 clinical medicine Arctic medicine. Tropical medicine Internal medicine Humans Medicine Leukocytosis Retrospective Studies Hantavirus pulmonary syndrome Respiratory distress business.industry Middle Aged medicine.disease Female Original Article Hantavirus infections medicine.symptom business Hantavirus Infection Brazil Hantavirus |
| Zdroj: | Revista do Instituto de Medicina Tropical de São Paulo, Vol 61 (2019) Revista do Instituto de Medicina Tropical de São Paulo Revista do Instituto de Medicina Tropical de São Paulo; Vol. 61 (2019); e55 Revista do Instituto de Medicina Tropical de São Paulo; v. 61 (2019); e55 Instituto de Medicina Tropical (IMT) instacron:IMT |
| ISSN: | 1678-9946 0036-4665 |
| DOI: | 10.1590/s1678-9946201961055 |
| Popis: | The hantavirus cardiopulmonary syndrome is considered an emerging disease in the Americas. Since 1993, thousands of cases have been reported from different countries, but mainly from Brazil. This study aims to describe some epidemiological, clinical and anatomopathological aspects of patients with hantavirus who presented poor outcome and were autopsied in a teaching hospital in Brazil, from 2000 to 2014. Of the 10 patients included, nine were male (mean age 43.5 years) and seven reported previous contact with rodents. Fever was present in eight of ten patients, dyspnea in nine of ten and myalgia in seven of ten patients; hemoconcentration, leukocytosis, thrombocytopenia and renal involvement were evidenced in all the 10 cases. At autopsy, the main alterations were seen in the lungs: pleural effusion (8/10 cases), increased weight 2.5 to 3 times, congestion/edema (10/10), interstitial mononuclear inflammation (10/10), alveolar hemorrhage (7/10), pulmonary collapse (7/10), hyaline membranes (7/10) and alveolar neutrophilic infiltrate (2/10). Pericardial effusion (2/10), mild myocardium inflammation (4/10), right ventricle dilation (1/10), polyploidy nuclei (3/10) and pericardial diffuse petechial (1/10) were also observed. The other organs exhibited discrete and non-specific alterations. Currently, this syndrome continues to be associated with high mortality directly linked to a late diagnosis and/or a misdiagnosis in the medical centers where these patients were seen for the first time. The anatomopathological findings at autopsy revealed the final phase of the process with pulmonary alterations, allowing a direct correlation with the severity of respiratory distress observed in these patients at admission. |
| Databáze: | OpenAIRE |
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