Iodine-125 Radioactive Seed Brachytherapy As a Treatment for Spine and Bone Metastases: A Systematic Review and Meta-Analysis
| Autor: | Salah G. Aoun, Ruhi Sharma, Maryam Haider, Kessiena L. Aya, Shaleen N. Vira, Ishaan K. Sharma, Navraj Sagoo, Matthew Igbinigie, Ali S Haider, Neha Sharma |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Radioactive seed medicine.medical_treatment Brachytherapy Analgesic Salvage therapy chemistry.chemical_element Bone Neoplasms Cochrane Library Iodine 030218 nuclear medicine & medical imaging Iodine Radioisotopes 03 medical and health sciences Neoplasm Seeding 0302 clinical medicine Humans Medicine Cement augmentation Spinal Neoplasms business.industry 125i seed Spine (zoology) Oncology chemistry 030220 oncology & carcinogenesis Meta-analysis Surgery Radiology business |
| Zdroj: | Journal of the American College of Surgeons. 233:e176 |
| ISSN: | 1072-7515 |
| DOI: | 10.1016/j.jamcollsurg.2021.08.476 |
| Popis: | Aim To evaluate the analgesic efficacy, safety, and local tumor control of iodine-125 (125I) seed brachytherapy (BT) for the management of spine and bone metastases. Methods A systematic literature search was conducted using PubMed, the Cochrane Library, and Scopus databases. Data regarding patient demographics, tumor characteristics, procedural parameters, and clinical outcomes were extracted and analyzed. Results Fourteen studies (7 prospective, 7 retrospective) were included, accounting for 689 patients, in our review. Analgesic efficacy was assessed at baseline and various postoperative time points. Significant improvement in pain was noted at 4- and 24-week follow-ups (p Conclusion 125I seed BT, alone or in conjunction with cement augmentation, may be a viable salvage therapy in appropriately selected patients. However, further studies are needed to analyze the long-term efficacy of this intervention as a palliative and curative modality. |
| Databáze: | OpenAIRE |
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