Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome
| Autor: | Torbjörn K. Nilsson, Andres Salumets, Annica Hoas, Agneta Skoog Svanberg, Signe Altmäe, Theodora Kunovac Kallak, Tiina Murto, Agneta Yngve, Kjell Wånggren, Anneli Stavreus-Evers |
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| Jazyk: | angličtina |
| Předmět: |
Infertility
Adult medicine.medical_specialty Homocysteine medicine.medical_treatment Physiology Fertilization in Vitro Polymorphism Single Nucleotide Statistics Nonparametric Hospitals University 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Folic Acid Pregnancy Reference Values Medicine Humans Prospective Studies Methylenetetrahydrofolate Reductase (NADPH2) 030304 developmental biology Sweden 0303 health sciences 030219 obstetrics & reproductive medicine In vitro fertilisation Chi-Square Distribution biology business.industry Obstetrics Pregnancy Outcome Obstetrics and Gynecology Genetic Variation General Medicine medicine.disease Folic acid supplementation Folic acid chemistry Methylenetetrahydrofolate reductase Case-Control Studies Dietary Supplements Folic acid intake biology.protein Female business Infertility Female |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica |
| ISSN: | 0001-6349 |
| DOI: | 10.1111/aogs.12522 |
| Popis: | To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677CT, 1298AC and 1793GA polymorphisms. Also the use of folic acid supplements, folate status and the frequency of different gene variations were studied in women undergoing infertility treatment and fertile women.Observational study.University hospital.Women undergoing infertility treatment and healthy, fertile, non-pregnant women.A questionnaire was used to assess general background data and use of dietary supplements. Blood samples were taken to determine plasma folate and homocysteine levels, and for genomic DNA extraction. A comparison of four studies was performed to assess pregnancy outcome in relation to MTHFR 677 TT vs. CC, and 1298 CC vs. AA polymorphisms.Folic acid supplement intake, and plasma folate, homocysteine and genomic assays.Women in the infertility group used significantly more folic acid supplements and had better folate status than fertile women, but pregnancy outcome after fertility treatment was not dependent on folic acid intake, folate status or MTHFR gene variations.High folic acid intakes and MTHFR gene variations seem not to be associated with helping women to achieve pregnancy during or after fertility treatment. |
| Databáze: | OpenAIRE |
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