Ropivacaine plus lidocaine versus bupivacaine plus lidocaine for peribulbar block in cataract surgery: A prospective, randomized, double-blind, single-center, comparative clinical study
| Autor: | Suryanarayana Murthy Upadhyayula, Venkata Ramanareddy Moolagani, Shanker Rao Burla, Anusha Bikkina, Bhaskara Rao Neethipudi, Narasimha Rao Arepalli |
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| Rok vydání: | 2020 |
| Předmět: |
Side effect
Lidocaine medicine.medical_treatment lcsh:RS1-441 Hemodynamics hyaluronidase Single Center lcsh:RD78.3-87.3 lcsh:Pharmacy and materia medica Hyaluronidase Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Bupivacaine ropivacaine business.industry Ropivacaine peribulbar block Cataract surgery Anesthesiology and Pain Medicine lcsh:Anesthesiology Anesthesia lidocaine Original Article business medicine.drug |
| Zdroj: | Journal of Anaesthesiology, Clinical Pharmacology Journal of Anaesthesiology Clinical Pharmacology, Vol 35, Iss 4, Pp 498-503 (2019) |
| ISSN: | 0970-9185 |
| Popis: | Background and Aims: Cataract surgery in ophthalmology is usually done under peribulbar block with a mixture of 0.5% bupivacaine and 2% lidocaine. Several case reports of fatalities associated with bupivacaine has necessitated a search for alternative safe agents. The aim of this study was to compare peribulbar block characteristics using a mixture of 0.5% bupivacaine and 2% lidocaine with a mixture of 0.5% ropivacaine and 2% lidocaine. Material and Methods: Eighty patients were allocated to two random groups of 40 each. Patients of groups BL and RL were given 4 ml of 0.5% bupivacaine and 4 ml of 0.5% ropivacaine each in a mixture with 4 ml of 2% lidocaine and 100 IU of hyaluronidase respectively. Block characteristics, hemodynamic variables, adverse drug interactions and other complications were recorded. Results: Demographic characteristics were comparable in both the groups. Duration of onset of the block and the side effect profile was comparable in both the groups but the total duration of the block and the time for first rescue analgesia was found to be longer in group BL than in group RL. Conclusions: Ropivacaine 0.5% and lidocaine 2% as a 1:1 mixture in a volume of 8 ml with 100 IU of hyaluronidase is as effective as a 1:1 mixture of bupivacaine 0.5% and lidocaine 2% in a volume of 8 ml with 100 IU of hyaluronidase with regards to onset and total duration of the block and side effects and hemodynamic changes. |
| Databáze: | OpenAIRE |
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