Maturation of cellular defence in the respiratory tract of young calves
| Autor: | F.J. Bourne, S.P. Yeo, F.G.R. Taylor, Christopher R. Stokes |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cell type
Staphylococcus aureus Time Factors Neutrophils Defence mechanisms Immunoglobulins Cell Count Biology Polymorphonuclear Neutrophils Macrophages Alveolar medicine Animals Longitudinal Studies Lymphocytes General Veterinary medicine.diagnostic_test Chemotaxis Peripheral blood Chemotaxis Leukocyte Bronchoalveolar lavage medicine.anatomical_structure Immunology Cattle Bronchoalveolar Lavage Fluid Intracellular Respiratory tract |
| Zdroj: | Research in veterinary science. 55(3) |
| ISSN: | 0034-5288 |
| Popis: | The maturation of respiratory tract defence was investigated in a longitudinal study of calves during the first 100 days of life. From day 7, the proportions of the cell types identified in bronchoalveolar lavage (BAL) fluid were similar to those found in adults, with a predominance of alveolar macrophages over polymorphonuclear neutrophils (PMNs) and lymphocytes. Functionally, bactericidal activity of BAL cells was defective and for the first 21 days they supported intracellular bacterial growth. At 24 hours of life, the movement of peripheral blood neutrophils to a chemotactic source was poor, but this increased rapidly during the first week of life. Like BAL cells, peripheral blood PMNs supported intracellular bacterial growth for the first two weeks of life. These studies suggest that cellular defence mechanisms may be compromised during the first week of life. |
| Databáze: | OpenAIRE |
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