SCDT-48. CONVECTION-ENHANCED DELIVERY OF CETUXIMAB CONJUGATED IRON-OXIDE NANOPARTICLES FOR TREATMENT OF SPONTANEOUS CANINE INTRACRANIAL GLIOMAS

Autor:	E. W. Howerth, Simon R. Platt, Costas G. Hadjipanayis, Freeman A, Alexandros Bouras, Eagleson J, Robinson K, Milota Kaluzova
Rok vydání:	2017
Předmět:	Cancer Research Cetuximab Chemistry Conjugated system digestive system diseases Abstracts chemistry.chemical_compound Oncology Cancer research medicine Neurology (clinical) Convection-Enhanced Delivery neoplasms Iron oxide nanoparticles medicine.drug
Zdroj:	Neuro-Oncology. 19:vi274-vi274
ISSN:	1523-5866 1522-8517
Popis:	Cetuximab conjugated iron-oxide nanoparticles (cetuximab-IONPs) have shown both in-vitro and in-vivo anti-tumor efficacy against gliomas. The purpose of this pilot study was to evaluate the safety and potential efficacy of cetuximab-IONPs for treatment of spontaneously occurring intracranial gliomas in canines after convection-enhanced delivery (CED). The use of CED allowed for direct infusion of the cetuximab-IONPs both intratumorally and peritumorally avoiding the blood brain barrier (BBB) and limiting systemic effects. A total of 8 dogs participated in the study and only 2 developed mild post-operative complications, which resolved with medical therapy. All canines underwent a single CED treatment of the cetuximab-IONPs over 3 days awake and did not receive any further adjuvant treatments. Volumetric analysis showed a median reduction in tumor size of 54.9 % by MRI at one-month follow-up. Five dogs were euthanized due to recurrence of neurological signs other than seizures, two due to recurrent seizures, and one dog died in his sleep. Median survival time (MST) after surgery was 248 days (mean 367 days).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1d06be97720ee2d69e04c415c1ab84 https://doi.org/10.1093/neuonc/nox168.1127 Zobrazit plný text záznamu