Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients

Autor: Matteo Cadossi, Luca Cevolani, Davide Maria Donati, Francesca de Terlizzi, Giuseppe Bianchi, Enrico Bonicoli, Giovanni Ciani, Francesco Benazzo, Leo Massari, François Cornelis, Daniele Screpis, Mario Mosconi, Costantino Errani, Barbara Rossi, Flavio Fazioli, Michele Boffano, Andrea Tognù, M. Nicolosi, Paolo Spinnato, Laura Campanacci, Giancarlo Facchini, Raimondo Piana
Přispěvatelé: Campanacci L., Bianchi G., Cevolani L., Errani C., Ciani G., Facchini G., Spinnato P., Tognu A., Massari L., Cornelis F.H., Mosconi M., Screpis D., Benazzo F., Rossi B., Bonicoli E., Fazioli F., Nicolosi M., Boffano M., Piana R., De Terlizzi F., Cadossi M., Donati D.M.
Rok vydání: 2021
Předmět:
Male
Electrochemotherapy
Palliative care
Bone disease
medicine.medical_treatment
Bone Nails
030218 nuclear medicine & medical imaging
Antineoplastic Agent
Electrochemotherapy (ECT)
0302 clinical medicine
Prospective Studies
Prospective cohort study
Pain control
Aged
80 and over
Cancer Pain
General Medicine
Middle Aged
Bone metastases
Metastatic bone disease (MBD)
Fracture Fixation
Intramedullary
Oncology
030220 oncology & carcinogenesis
Disease Progression
Female
Radiology
Human
Adult
medicine.medical_specialty
Fractures
Spontaneou
Antineoplastic Agents
Bone Neoplasms
Bone Neoplasm
behavioral disciplines and activities
NO
03 medical and health sciences
Breast cancer
mental disorders
medicine
Humans
Adverse effect
Response Evaluation Criteria in Solid Tumors
Aged
Bone Nail
business.industry
medicine.disease
Radiation therapy
Bone metastase
Prospective Studie
Fractures
Spontaneous
Quality of Life
Surgery
business
Progressive disease
Zdroj: European Journal of Surgical Oncology. 47:2609-2617
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2021.05.004
Popis: Introduction Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions. Materials and methods 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered. Results 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up. Conclusion The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy.
Databáze: OpenAIRE
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