Toxoplasmahistone acetylation remodelers as novel drug targets
| Autor: | William J. Sullivan, Laura Vanagas, Silvina S. Bogado, Victoria Jeffers, Sergio O. Angel, Maria Carolina Dalmasso |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Molecular Sequence Data Biology Microbiology Article Histone Deacetylases Histones Virology parasitic diseases Humans Nucleosome Amino Acid Sequence Histone Acetyltransferases Genetics Histone deacetylase 5 Antiparasitic Agents HDAC11 Histone deacetylase 2 HDAC10 Acetylation Chromatin Nucleosomes Cell biology Histone Deacetylase Inhibitors Infectious Diseases Histone biology.protein Histone deacetylase Protein Processing Post-Translational Sequence Alignment Toxoplasma Toxoplasmosis |
| Zdroj: | Expert Review of Anti-infective Therapy. 10:1189-1201 |
| ISSN: | 1744-8336 1478-7210 |
| Popis: | Toxoplasma gondii is a leading cause of neurological birth defects and a serious opportunistic pathogen. The authors and others have found that Toxoplasma uses a unique nucleosome composition supporting a fine gene regulation together with other factors. Post-translational modifications in histones facilitate the establishment of a global chromatin environment and orchestrate DNA-related biological processes. Histone acetylation is one of the most prominent post-translational modifications influencing gene expression. Histone acetyltransferases and histone deacetylases have been intensively studied as potential drug targets. In particular, histone deacetylase inhibitors have activity against apicomplexan parasites, underscoring their potential as a new class of antiparasitic compounds. In this review, we summarize what is known about Toxoplasma histone acetyltransferases and histone deacetylases, and discuss the inhibitors studied to date. Finally, the authors discuss the distinct possibility that the unique nucleosome composition of Toxoplasma, which harbors a nonconserved H2Bv variant histone, might be targeted in novel therapeutics directed against this parasite. |
| Databáze: | OpenAIRE |
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