Prospective surveillance of hospitalisations associated with varicella-zoster virus infections in children and adolescents
| Autor: | Jan Bonhoeffer, Urs B. Schaad, Ulrich Heininger, David Nadal, Beda Muehleisen, Gurli Baer, Christoph Aebi |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent medicine.disease_cause Herpes Zoster Immunocompromised Host Chickenpox Seroepidemiologic Studies Intensive care Epidemiology medicine Humans Prospective Studies Prospective cohort study Child Pneumonitis Varicella Zoster Infection Likelihood Functions business.industry Varicella zoster virus Infant Newborn Infant medicine.disease Hospitalization Child Preschool Pediatrics Perinatology and Child Health Female business Complication Switzerland |
| Zdroj: | European journal of pediatrics. 164(6) |
| ISSN: | 0340-6199 |
| Popis: | Our goal was to determine the epidemiology of severe varicella-zoster virus (VZV) infections in hospitalised paediatric patients. Admissions associated with VZV infection of patients aged 0–16 years were reported by all 38 paediatric units in Switzerland to the Swiss Paediatric Surveillance Unit (SPSU) during 3 consecutive years (4/2000–3/2003). We verified completeness of reporting by capture-recapture analysis with patient records identified by ICD-10 codes. Outcome of illness was assessed 6 months after hospitalisation. A total of 335 cases (235 identified by SPSU reports, 100 by ICD-10 code) were included in this study. Mean age of patients was 4.1 years (median 3.5 years, range 0–16 years); 54% were male. Some 293 (87%) patients presented with chickenpox, 42 (13%) with herpes zoster and 291 (87%) patients were not immunocompromised. A total of 319 complications occurred in 237 (71%) patients: secondary bacterial infections (n =109); central nervous system involvement (n =76); VZV pneumonitis (n =7); others (n =127). Eleven (3%) patients required intensive care and three died. On follow-up, 303 (96%) of 315 patients had completely recovered; sequelae were present in 12 (4%) patients. The calculated hospitalisation rate was 13 per 104 cases. Conclusion:This study describes a sizeable hospitalisation and complication rate of varicella-zoster virus infections and provides a solid basis for future immunisation recommendations in Switzerland. |
| Databáze: | OpenAIRE |
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