Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT
| Autor: | Laurence S C Lok, Sarah Heard, Charlotte Summers, A. Michael Peters, John R. Buscombe, Stephen D. Preston, Uta Hill, Daniel Gillett, Mark Southwood, Edwin R. Chilvers, Chrystalla Loutsios, Nicola Tregay, Doris Rassl, Neda Farahi, Robert C. Rintoul |
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| Přispěvatelé: | Preston, Stephen Denis [0000-0002-6836-3591], Rintoul, Robert Campbell [0000-0003-3875-3780], Chilvers, Edwin R [0000-0002-4230-9677], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Pathology medicine.medical_specialty Lung Neoplasms Chest clinic Neutrophils Early lung cancer Biopsy Respiratory System digestive system 03 medical and health sciences 0302 clinical medicine medicine Humans Lung cancer 030304 developmental biology Neoplasm Staging chemistry.chemical_classification Tomography Emission-Computed Single-Photon 0303 health sciences biology business.industry Indium Radioisotopes neutrophil biology 1103 Clinical Sciences imaging/CT MRI etc medicine.disease 3. Good health lung cancer chemistry Transferrin 030220 oncology & carcinogenesis Myeloperoxidase biology.protein Female Non small cell Lung tumours business |
| Zdroj: | Thorax |
| Popis: | Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer. |
| Databáze: | OpenAIRE |
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