Effect of administration of high-protein diet in rats submitted to resistance training
| Autor: | Amílcar Sabino Damazo, Géssica Alves Fraga, Thiago da Rosa Lima, Fabrício Azevedo Voltarelli, Joice Cristina dos Santos Trombeta, James W. Navalta, Mariana de Souza Sena, Paula Caroline de Almeida, Arlyson Batista de Souza Dias, Jonato Prestes, Roberto Carlos Vieira Junior, Eudes Thiago Pereira Avila |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Protein metabolism Medicine (miscellaneous) Blood sugar Blood lipids High-protein diet Biology Kidney Muscle Development medicine.disease_cause Excretion Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Internal medicine medicine Animals Urea Rats Wistar Muscle Skeletal Triglycerides Hypertriglyceridemia Soleus muscle Creatinine 030109 nutrition & dietetics Nutrition and Dietetics Cholesterol HDL Resistance Training Hypertrophy Organ Size 030229 sport sciences Endocrinology Liver chemistry Hyperglycemia Diet High-Protein Biomarkers |
| Zdroj: | European Journal of Nutrition. 57:1083-1096 |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-017-1391-5 |
| Popis: | Although there is limited evidence regarding the pathophysiological effects of a high-protein diet (HD), it is believed that this type of diet could overload the body and cause damage to the organs directly involved with protein metabolism and excretion. The aim of this study was to verify the effects of HD on biochemical and morphological parameters of rats that completed a resistance training protocol (RT; aquatic jump) for 8 weeks. Thirty-two adult male Wistar rats were divided into four groups (n = 8 for each group): sedentary normal protein diet (SN-14%), sedentary high-protein diet (SH-35%), trained normal protein diet (TN-14%), and trained high-protein diet (TH-35%). Biochemical, tissue, and morphological measurements were made. Kidney (1.91 ± 0.34) and liver weights (12.88 ± 1.42) were higher in the SH. Soleus muscle weight was higher in the SH (0.22 ± 0.03) when compared to all groups. Blood glucose (123.2 ± 1.8), triglycerides (128.5 ± 44.0), and HDL cholesterol levels (65.7 ± 20.9) were also higher in the SH compared with the other experimental groups. Exercise reduced urea levels in the trained groups TN and TH (31.0 ± 4.1 and 36.8 ± 6.6), respectively. Creatinine levels were lower in TH and SH groups (0.68 ± 0.12; 0.54 ± 0.19), respectively. HD negatively altered renal morphology in SH, but when associated with RT, the apparent damage was partially reversed. In addition, the aquatic jump protocol reversed the damage to the gastrocnemius muscle caused by the HD. A high-protein diet promoted negative metabolic and morphological changes, while RT was effective in reversing these deleterious effects. |
| Databáze: | OpenAIRE |
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