Switching to antipsychotic monotherapy vs. staying on antipsychotic polypharmacy in schizophrenia: A systematic review and meta-analysis
| Autor: | Hiroki Yamada, Shotaro Takasu, Hiroyoshi Takeuchi, Naoki Hashimoto, Yoshiteru Takekita, Ken Inada, Kentaro Matsui, Yoshio Yamanouchi, Taishiro Kishimoto, Hideaki Tani, Seiichiro Tarutani, Tetsufumi Kanazawa, Takahiro Tokumasu |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment law.invention 03 medical and health sciences 0302 clinical medicine Deprescriptions Extrapyramidal symptoms Randomized controlled trial law Internal medicine medicine Humans Antipsychotic Biological Psychiatry Polypharmacy business.industry Drug Substitution Patient Selection medicine.disease 030227 psychiatry Discontinuation Psychiatry and Mental health Psychotic Disorders Schizophrenia Meta-analysis Drug Therapy Combination medicine.symptom business 030217 neurology & neurosurgery Psychopathology Antipsychotic Agents |
| Zdroj: | Schizophrenia research. 209 |
| ISSN: | 1573-2509 |
| Popis: | While recent meta-analyses have reported the superiority of antipsychotic polypharmacy (APP) over antipsychotic monotherapy (APM) in schizophrenia, switching to APM can be beneficial in terms of side effects. To determine whether patients receiving APP should switch to APM or stay on APP, we conducted a systematic review and meta-analysis.Randomized controlled trials (RCTs) examining a switch from APP to APM vs. staying on APP were systematically selected from a previous meta-analysis comparing APP with APM in patients with schizophrenia. In addition, we conducted an updated systematic literature search using MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. Data on study discontinuation, relapse, psychopathology, neurocognition, extrapyramidal symptoms, and body weight/body mass index (BMI) were extracted and synthesized.A total of 6 RCTs involving 341 patients were included. All studies examined a switch from 2 antipsychotic agents to a single agent. Clozapine-treated patients were included in 3 studies. There was a significant difference in study discontinuation due to all causes in favor of staying on APP (N = 6, n = 341, RR = 2.28, 95% CI = 1.50-3.46, P 0.001). There were no significant differences in relapse, any psychopathology, neurocognition, extrapyramidal symptoms, or body weight/BMI between the 2 groups. The quality of evidence was low to very low.The findings suggest that clinicians should closely monitor patient condition when switching to APM after receiving 2 antipsychotics. Given the low to very low overall quality of the evidence, the findings should be considered preliminary and inconclusive. |
| Databáze: | OpenAIRE |
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